HYDROXYAPATITE
&
NANO HYDROXYAPATITE POWDER
HYDROXYAPATITE POWDER AND NANO HYDROXYAPATITE POWDER
Hydroxyapatite and Nano Hydroxyapatite is biocompatible as well as osteoconductive and osteotransducive material Hydroxyapatite powder uses in Biomedical as well as Oral Care Products. Specific uses dictate the choice of the forms of Hydroxyapatite that can be used. Our Hydroxyapatite & Nano Hydroxyapatite are purely synthetic and do not involve any component of animal origin. Hydroxyapatite is [Ca10(PO4)6(OH)2], and resembles the human bone.
Hydroxyapatite and Nano hydroxyapatite are used as artificial bone materials for 3D printing, Bone Repair, as well as Bone Coating & Bone Filling. Thermal spraying is used for coating femoral components.
OUR BRANDS & USES
3D Printing
Thermal Spraying
Bone Coating
Bone Repair
Bone Filling
Toothpastes
Mouthwashes
Artificial Bone
(Bone grafts)
Bone Scaffolds
(for bone defect reconstruction)
Soil Remediation
Face wash
Creams
Dermal filler
3D Printing
Thermal Spraying
Bone Coating
Bone Repair
Bone Filling
AIMTITE HYDROXYAPATITE POWDER
AIMTITE Hydroxyapatite powder is a synthetic micro Hydroxyapatite powder generally of spherical shape. For the most part, these are most suited for application in 3D printing, Thermal spraying, Plasma Spraying, bone coating, bone repair & bone filling & synthetic bone substitute. Usually, the average particle size is in microns to mm. Hydroxyapatite [Ca10(PO4)6(OH)2] is an example of a bio-ceramic inorganic compound with a chemical composition similar to the bone. Hydroxyapatite undeniably is used as a material for bone substitute & thus finds applications in orthopedic implants & in the same manner in dentistry. Hydroxyapatite is used especially as a bioactive coat on metallic implants & all the more increases the bone & consequently the implant surface.
H Y D R O X Y A P A T I T E (SPHERICAL SHAPED)
A I M T I T E
| Application of Aimtite | Average Particle Sizes (μm) |
| 3D Printing | 15 100 200 |
| Thermal Spraying | 15 50 100 – 150 |
| Bone Coating | 50 |
| Bone Repair | 200 3mm |
| Bone Filling | 3mm |
AIMTITE Hydroxyapatite powder Uses: click here
The 3D printing of neat hydroxyapatite scaffolds is as a matter of fact difficult to obtain. To obtain target-specific scaffolds hydroxyapatite is either processed with sacrificial materials like polymers or other materials like ceramics or bioactive glass. Moreover, binders like polyacrylamide, PVA, sodium polyacrylate, maltodextrin, etc. thus are used. The 3D constructed components have controlled architecture and porosity. The hydroxyapatite “ink” can be cell-free or have cell-encapsulated materials. Various techniques & moreover, for example, β – Tricalcium phosphate, Calcium sulfate, silk-fibroin, graphene, CNTs etc. have been used to fabricate hydroxyapatite scaffolds.
Thermal Spraying Hydroxyapatite, [Ca10(PO4)6(OH)2], is used in biomedical applications including orthopedic device, dental replacements, tissue engineering & bioactive coating. Hydroxyapatite is used regularly for coating either metallic implants of SS316L or Titanium or Ti6Al4V due its excellent biocompatibility & bioactivity.
Hydroxyapatite stimulates strong a bond between metal & bone. Moreover, Hydroxyapatite coating shields the release of metallic ions of the implant into the body. Thermal spraying is an FDA-approved method for coating biomedical implants.
Thermal spraying uses
low flame temperature & high flow velocity of hydroxyapatite particles. For example, typical spray parameters for coating hydroxyapatite on implants are as follows & usually will vary according to the type of equipment & the hydroxyapatite used:
Acetylene flow rate: 70 – 75 Lit/minute
Oxygen flow rate: 40 – 45 Lit/minute
Air pressure: 4 – 5 kg/cm2
Powder feed rate: 15 gm/minute
Spray distance: About 10 cm
Thermal spraying based techniques produce thick coatings of several tens of micrometers, even though the use of a feedstock as a solution or suspension can result in thinner coatings (5 to 10 μm) when compared with thermal spraying when using dry powders.
Knee implants – Hydroxyapatite coatings have also been used in un – cemented knee prostheses, with coatings applied by plasma spraying to the femoral &/or tibial components. These have more than 20 years of clinical use. For un-cemented hips, the use of un-cemented knee prostheses is generally, for most part, recommended for younger patients (< 60 years).
Hydroxyapatite coat on above metal substrates is done using four methods: Click Here
Plasma-Spray Method is above all used for coating o dental & orthopedic implants. A coating on Titanium or Ti6Al4V can be achieved using this method for the most part. Thinner films of hydroxyapatite ordinarily can be deposited on metal substrates using Suspension Plasma Spray (SPS).
Usually adding Titanium to Hydroxyapatite improves the bonding strength of the coating from about 14.5 to 17.3 MPa. Not to mention that an increase in the adhesion of the coating layer to the implant can be observed if Titanium content increases.
Hydroxyapatite reinforced with 10%w/w of a mix of 80Al2O3 +20TiO2 on Ti6Al4V, moreover, enhances adhesion strength in this case to above 32 MPa.
Sol-Gel Dip Coating Method for applying hydroxyapatite layers involves the formation of Sol-Gel using Calcium Nitrate & Phosphorus pentoxide or triethyl phosphate using aqueous or alcoholic solvents for the most part. Moreover, this is followed by dipping the substrate into the sol-gel over time. It is simply subsequently withdrawn & then dried.
This process is thus simple, fast, cheap & in particular, allows uniform deposition of hydroxyapatite onto complex surfaces at low temperatures.
Electrochemical The electrochemical Deposition Method in particular allows progressive nucleation & growth of hydroxyapatite coat. This leads to a demonstrably homogenous deposition, controlled thickness & reduced decomposition of the hydroxyapatite layer. Besides, Cathodic deposition systems used are either Electrophoretic or Electrolytic.
Likewise, Graphite or Platinum are used as anodes. Hydroxyapatite can additionally be combined with CNTs, ZrO2, TiO2, etc. to achieve better properties. The following table is guidance, comparing electrodeposition methods drawn from various references.
High-Velocity Suspension Plasma Spraying (HVSPS) Method for coating metal substrates, by all means, enhances bioactivity, prevents wearing & corrosion of implants as well as controls the release of harmful metal ions in the body. This method is especially widely used.
The High-Velocity Oxygen-Fuel (HVOF) allows for the formation of a suspension spraying layer. In the same manner, the high velocity of powders allows the formation of a uniform protective coat with low porosity.
Fine or Nano Powders of Hydroxyapatite can be thermally sprayed directly using plasma or gas jets. Aqueous medium &/or Diethylene Glycol suspensions of hydroxyapatite can also be used. Additionally, the coating produced does not delaminate from the substrate significantly.
Toothpastes
Mouthwashes
TOOTITE NANO HYDROXYAPATITE FOR USE IN ORAL CARE PRODUCTS
TOOTITE Nano Hydroxyapatite powder & micro hydroxyapatite powders. They are acicular, spherical/acicular-like or spherical shaped. They are used in manufacturer of toothpastes and mouthwashes. The average particle sizes range from microns to nm. A Nano Hydroxyapatite is similar to the human tooth enamel by morphology and crystal structure. Nano Hydroxyapatite are incorporated in oral care formulations to treat dentin hypersensitivity and promote remineralisation and restoration of the dental enamel.
Lesions of tooth enamel expose the dentine tubules. The exposed dentine tubules are thus subject to different stimuli in the mouth, which reaches the pulp and causes sharp pain.the Nano Hydroxyapatite reduces this pain as the Nano particles are so small that they can enter and fill the dentin tubules.
For Nano Hydroxyapatite particles precipitate inside the dentin tubules and block the interaction of nerves to the external stimuli. It can also precipitate onto the surface of enamel of the tooth and remineralize the dental caries by forming a new apatite layer.
The new apatite layer so formed is hard, making teeth stronger and prevents tooth decay.
TOOTITE (Nano Hydroxyapatite) resembles human teeth in composition. It is used in dentifrice formulations like toothpastes, mouthwashes and toothpaste tablets. It offers excellent tooth enamel remineralization of damage caused by dental caries & removes tartar. It offers an excellent alternative to fluoride-based dental products.
Level Of Use Of Nano Hydroxyapatite – TOOTITE
Toothpastes and Toothpaste Tablets : 5 to 15% w/w
Mouthwashes :15.5 % suspension in water.
The suspensions can be sterilized by autoclaving at 1200C for 15 minutes without affecting the properties of Nano Hydroxyapatite.
We offer TOOTITE (Nano & Micro Hydroxyapatite) in various particle sizes for use in dental & bone care formulations. TOOTITE is obtained from natural mineral sources & not from animal sources. The product is TSE/BSE free.
TOOTITE is offered in well-defined characteristics as follows:
| Particle Morphology | Average Particle Size | Ordering Information |
| Spherical | 2 µm | TOOTITE-2 |
| Spherical/Acicular-like | 200 nm | TOOTITE-200 |
| Acicular | 40 nm | TOOTITE-40 |
AN INTERESTING ADDITIVE – AIRGO (GRAPHENE) IN TOOTHPASTES click here
Artificial Bone
(Bone grafts)
Bone Scaffolds
(for bone defect reconstruction)
BONITE HYDROXYAPATITE POWDER
BONITE Nano Hydroxyapatite Powder of either acicular (needle-shaped) or short – road like in morphology. These nano powder are best suited for artificial bone (bone grafts), bone scaffolds (for bone defect reconstruction). The average particle sizes are 20 nm.
BONITE
NANO HYDROXYAPATITE
APPLICATION: Artificial Bone (Bone grafts), Bone Scaffolds (for bone defect reconstruction)
| Particle Morphology | Average particle Size | Phase Purity |
| Acicular | 20nm | 97.5% or 99% |
| Short rod-like | 20nm | 99% |
Soil Remediation
SOILTITE Nano Hydroxyapatite And Micro Hydroxyapatite Powder
SOILTITE Nano Hydroxyapatite powder & micro hydroxyapatite powder. They are Spherical, Spherical / Acicular – like or acicular shaped. SOILTITE Nano Hydroxyapatite used in soil remediation for different solutions. The average particle sizes range from microns to nm.
Presence of heavy metals in soils is a serious environmental issue and is transported to living beings via the food chain. SOILTITE Nano Hydroxyapatite in different particle sizes are used. SOILTITE Nano Hydroxyapatite effectively immobilizes lead, zinc, copper, cadmium, arsenic in soil contaminated with these elements. Improvement of growth of maize and bean plants have been observed by addition of 0.5 % to 1% Hydroxyapatite to the soil. Higher percentages need to be used judiciously.
Addition of Nano Hydroxyapatite to the soil showed decreased accumulation of Cadmium in rape plant and cabbage. The phosphatase activity in soil increased after adding Nano Hydroxyapatite. Typical use levels for remidiation are 15 g/kg.
SOILTITE
NANO HYDROXYAPATITE
APPLICATION: SOIL REMEDIATION
| Particle Morphology | Average Particle Size | Phase Purity |
| Spherical | 80 μm | 99% |
| Spherical | 2 μm | 96% |
| Spherical / Acicular-like | 200 nm | 96% |
| Acicular | 40 nm or 60 nm | 96% |
Face wash
Creams
Dermal filler
COSMETITE Nano Hydroxyapatite Powder Use In Cosmetics
COSMETITE – 40 is Nano hydroxyapatite Powder made from natural mineral sources & is TSE/BSE free. It is acicular in nature and has an average crystallite size of 40 nm.
COSMETITE-40 has excellent protein adsorption properties & hence can remove dirt & dead cells of skin, gently, without damaging the skin. This allows making face wash formulations without the use of harsh exfoliating or scrubbing ingredients.
COSMETITE-40 accelerates collagen production (by stimulating cells called fibroblasts) which is responsible for structure, elasticity & firmness of the skin.
Hydroxyapatite used as Dermal filler for
- Wrinkles
- Nasolabial Folds
- Marionette Lines
- Pre-jowl Sulcus
- Chin Lines
- Acne Scars
- Tear Trough Depressions
